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KMID : 0390020070170030271
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Pediatric Allergy and Respiratory Disease
2007 Volume.17 No. 3 p.271 ~ p.281
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Clinical Features of the 15 Patients with Idiopathic Interstitial Pneumonia.
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Park Su-Hwa
Ahn Yeon-Hwa
Han Joung-Ho
Kim Jhin-Gook
Ahn Kang-Mo
Lee Sang-Il
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Abstract
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Purpose : Histologic classification plays a key role in the classification of idiopathic interstitial pneumonia (IIP) into clinically meaningful categories in terms of natural history, prognosis and treatment. The implications of histological diagnosis, clinical features and prognosis in children has not been described. This study aimed to analyze the clinical features of IIP in children.
Methods : A total of 15 patients with IIP were recruited, who had a surgical lung biopsy. The age, sex, symptoms, initial oxygen saturation, radiologic findings and clinical courses were retrospectively investigated.
Results : The median age at diagnosis was 3 years. Cough (93.3%), tachypnea (86.7%) and dyspnea (80%) were the most common symptoms, and laboratory findings were nonspecific. Acute interstitial pneumonia (n=6), chronic pneumonitis of infancy (n=4) nonspecific interstitial pneumonia (n=3) were relatively common. All patients received corticosteroid therapy and the mortality rate was 26.7% (n=4).
Conclusion : IIP has diverse clinical features according to subtypes. Knowledge of the underlying histopathology will allow the prediction of more accurate prognosis, the decision of appropricate therapy, and the clinical investigation of novel therapeutic agents in patients with IIP.
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KEYWORD
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Idiopathic interstitial pneumonia, Biopsy, Children
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